Advanced Studies in Oncology
Case-Based Discussion of Emerging Evidence Pre-Test
Page 1 of 1
1.
According to results of the study conducted by Gauden et al, which of the following statements regarding surgical resection of glioblastoma multiforme (GBM) is most accurate?
*
Patients who undergo complete macroscopic excision experience a longer median overall survival (OS) than those who are treated with partial resection or biopsy.
Patients who undergo complete macroscopic excision experience a significantly longer median OS than those who are treated with biopsy; survival time is not significantly different between complete macroscopic excision and partial resection.
There is no significant difference in median OS between patients who undergo partial resection and those who are treated with a biopsy.
The extent of surgical resection does not have a significant effect on median OS.
2.
Results of the study conducted by Kreisl et al reveal that:
*
The combination of bevacizumab and irinotecan is more effective than bevacizumab alone for the treatment of recurrent glioblastoma.
Single-agent irinotecan is well-tolerated and has significant activity in patients with recurrent glioblastoma; the progression-free survival at 6 months compares favorably with historical controls of other regimens.
The addition of irinotecan to bevacizumab is futile in the treatment of recurrent glioblastoma.
Age and sex have no impact on clinical outcomes in recurrent glioblastoma.
3.
Based on the study conducted by Glas et al, which of the following findings is
TRUE
?
*
The combination of lomustine (CCNU), temozolomide (TMZ), and radiotherapy is effective in patients with newly diagnosed glioblastoma, but only in the short term.
CCNU/TMZ dose intensification adds a marked survival benefit without increasing toxicity.
Patients with glioblastoma with a non-methylated O
6
-methylguanine-DNA methyltransferase (MGMT) promoter in their tumor are the ones who generally benefit most from CCNU/TMZ chemotherapy.
CCNU and TMZ chemotherapy doses and MGMT promoter methylation status both influence median OS in patients with newly diagnosed glioblastoma.
4.
Which of the following statements regarding the study conducted by Martinez et al is
FALSE
?
*
Gross total resection (vs biopsy or subtotal resection) was associated with longer survival in both groups.
In both groups, the most common complications were of neurologic origin.
Survival rate at 12 and 24 months was 59.2% and 31.7%, respectively, in patients aged 65 years or older.
Older patients who had diabetes showed more regional neurological complications (especially cerebrospinal fluid leak).
5.
Results of the study conducted by Balik et al show that:
*
Histopathologically identical GBM tumors display marked immunophenotypic heterogeneity.
Expression of A2B5, CD56, NGFR, and Pgp appears to be associated with chemoresistance.
Expression of CD133, EGFR, and LIFR was characteristic of chemosensitive tumors.
All of the above
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